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Abacavir Sulphate

Abacavir Sulphate
Abacavir Sulphate
Product Code : 01
Product Description

Abacavir Sulphate, CAS No: 188062-50-2, C28H38N12O6S

Abacavir Sulfate is a Nucleoside Reverse Transcriptase Inhibitor (NRTI). Similar to the NRTIs this sulfate variety of abacavir works by blocking the HIV inverse transcriptase, which is an HIV enzyme. The product is an inhibitor or blockage for HIV-1 RT. This sulfate salt formation of abacavir, a nucleoside inverse transcriptase activator is an analogue of guanosine. The agent lessens the HIV viral scores, hinders or prevents the harm made to the immune system. It minimizes the risk of developing AIDS.

Abacavir Sulfate is a reverse transcriptase inhibitor and nucleoside analogue, which is utilized in accumulation with some other agents in the therapy or treatment of Human Immunodeficiency Virus (HIV) contagion and the Acquired Immunodeficiency Syndrome (AIDS). Abacavir is an extraordinary cause of objectively apparent drug evoked liver injury.

Application :-

The anti-HIV drug Abacavir Sulfate is a carbocyclic 2’-deoxyguanosine nucleoside reverse polymerase activator that is used to medicate HIV infection. Intracellular enzymes changes Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then by selection suppresses HIV reverse transcriptase byunifying into viral DNA (2). Metabolized in the liver by alcohol dehydrogenase and uridine diphosphate glucuronyltransferase consequent in inactive glucuronide and carboxylate metabolites, subsequently.

Precautions :-

Before consuming Abacavir, inform the doctor or chemist if you are sensitized to it; or if you are suffering with any other allergy. This product may comprise inactive ingredients, which can reason in allergic reactions or some other problems. Talk to your health care provider for further information.

Before taking this medicine, inform the doctor or chemist your medical history, particularly of: liver troubles (such as hepatitis B or C), cirrhosis of the liver, kidney difficulties, alcohol use.

Abacavir may raise the endangerment of a heart attack. Discourse about the risks and advantages of this medical treatment with your doctor and find the ways to lessen the risk of heart disease. In case if you smoke, or if you have some other states, which increase the endangerment of heart disease such as diabetes, high blood pressure, or high level of cholesterol.
Before you go for a surgery, inform the or dentist about all the medications you use (including prescription and nonprescription drugs, as well as herbal products).

The medication should be used with care during the days of pregnancy. It is safe if you consult the doctor. All the same, HIV medicines are now commonly suggested to pregnant women with HIV. Treatment can drop-off the risk of transiting the HIV infection to the baby. Discuss the perils and benefits with the doctor if Abacavir may be a part of that medical care.

This medicine has its way into breast milk as breast milk can carry HIV, so avoid the breast-feeding.

Details of  Abacavir Sulfate :-

  • Product name: Abacavir Sulfate
  • Synonyms: (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Sulfate; Ziagen
  • CAS Number: 188062-50-2
  • Molecular form.: C28H38N12O6S
  • Appearance: White to Off-White Solid
  • Melting Point: 213 - 214°C (dec.)
  • Mol. Weight: 670.74
  • Storage: -20°C Freezer
  • Solubility: Water, Methanol (Sparingly)
  • Category: Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals

 


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