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Take this medicine in the dose and duration as advised byyour doctor. Swallow it as a whole. Do not chew, crush or break it.Synbeta Tablet is to be taken with food.
Synbeta Tablet is a combination of two medicines:Amoxicillin and Sulbactam. Amoxicillin is an antibiotic. It works by preventingthe formation of the bacterial protective covering which is essential for thesurvival of bacteria. Sulbactam is a beta-lactamase inhibitor which reducesresistance and enhances the activity of Amoxicillin against bacteria.
Amoxicillin (Synbeta) is indicated inthe treatment of infections due to susceptible (ONLY ÃÂ²-lactamase-negative)strains of the designated microorganisms in the conditions listed below:
Infections of the ear, nose, and throat - due toStreptococcus spp. (ÃÂ±- and ÃÂ²-hemolytic strains only), S. pneumoniae,Staphylococcus spp., or H. influenzae.
Infections of the genitourinary tract - due to E. coli,P. mirabilis, or E. faecalis.
Infections of the skin and skin structure - due toStreptococcus spp. (ÃÂ±- and ÃÂ²-hemolytic strains only), Staphylococcus spp., orE. coli.
Adult & childn Ã¢ÂÂ¥40 kg 1.5-3 g 6 hrlyIV or IM. Childn Ã¢ÂÂ¥1 yr 300 mg/kg body wt IV infusionin equally divided doses 6 hrly. Max dose for Sulbactam (Synbeta):4 g/day.
Probenecid decreases the renal tubular secretion ofAmoxicillin (Synbeta). Concurrent use with Augmentin may result in increasedand prolonged blood levels of Amoxicillin (Synbeta). Coadministration ofprobenecid cannot be recommended.
Abnormal prolongation of prothrombin time (increasedinternational normalized ratio [INR]) has been reported rarely in patientsreceiving Amoxicillin (Synbeta) and oral anticoagulants. Appropriate monitoringshould be undertaken when anticoagulants are prescribed concurrently.Adjustments in the dose of oral anticoagulants may be necessary to maintain thedesired level of anticoagulation.
SYNBETA SIDE EFFECTS
Skin rashes, pruritus, urticaria, angioedema, serumsickness?like reactions (urticaria or skin rash accompanied by arthritis,arthralgia, myalgia, and frequently fever), erythema multiforme (rarelyStevens-Johnson syndrome), acute generalized exanthematous pustulosis,hypersensitivity vasculitis, and an occasional case of exfoliative dermatitis(including toxic epidermal necrolysis) have been reported. These reactions maybe controlled with antihistamines and, if necessary, systemic corticosteroids.Whenever such reactions occur, the drug should be discontinued, unless theopinion of the physician dictates otherwise. Serious and occasional fatalhypersensitivity (anaphylactic) reactions can occur with oral penicillin.