Productname : Adpaxil 260 mg
GenericName : Paclitaxel Injection
Manufacturer : Adley
Adpaxil belongs to the group of medicinescalled antineoplastics. It interferes with the growth of cancer cells, whichare eventually destroyed. Since the growth of normal body cells may also beaffected, other unwanted effects will also occur. Some of these may be seriousand must be reported to your doctor. Other effects may not be serious but maycause concern. Some effects may not occur until months or years after themedicine is used.
HOWSHOULD I USE ADPAXIL?
Use Adpaxil as directed by your doctor. Check the label on themedicine for exact dosing instructions.
Â§ Â§ Â§ If nausea, vomiting, diarrhea, or loss ofappetite occurs, do not discontinue your medicine. Ask your doctor orpharmacist for ways to lessen these effects.
Adpaxil is used alone or in combination withother chemotherapeutic agents in the treatment of ovarian cancer, breastcancer, advanced non-small cell lung cancer, cancer of pancreas, and AIDSrelated Kaposiâs sarcoma (a type of cancer that develops from the cells thatline lymph or blood vessels).
Ketoconazole: As ketoconazole may inhibit the metabolism of Adpaxil,patients receiving Adpaxil and ketoconazole should be closely monitored or thecombination of these drugs should be avoided.
Hematologic: Bonemarrow suppression was the major dose-limiting toxicity of Adpaxil.Neutropenia, the most important hematologic toxicity, was dose- andschedule-dependent and was generally rapidly reversible. Among patients treatedin phase 3 second-line ovarian study with a 3-hr infusion, neutrophil countsdeclined <500 cells/mm3 in 14% of patients treated with adose of 135 mg/m2compared to 27% at a dose of 175 mg/m2 (p=0.05).