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Brand Name:Â Care-O-Pet
ActiveIngredients :Â Carprofen
Country ofOrigin :Â India
IntendedPatient :Â Dogs
Carprofen is anon-steroidal anti-inflammatory drug (NSAID) of the propionic acid class thatincludes ibuprofen, naproxen, and ketoprofen. Carprofen is the nonproprietarydesignation for a substituted carbazole, 6-chloro-Ã¢ÂÂ-methyl-9H-carbazole-2-aceticacid. The empirical formula is C15H12ClNO2Â and the molecular weight273.72.
Carprofen is anon-narcotic, non-steroidal anti-inflammatory agent with characteristicanalgesic and antipyretic activity approximately equipotent to indomethacin inanimal models.1
The mechanism ofaction of Carprofen, like that of other NSAlDs, is believed to be associatedwith the inhibition of cyclooxygenase activity. Two unique cyclooxygenases havebeen described in mammals.2The constitutive cyclooxygenase, COX-1, synthesizesprostaglandins necessary for normal gastrointestinal and renal function. Theinducible cyclooxygenase, COX-2, generates prostaglandins involved ininflammation
As a class,cyclooxygenase inhibitory NSAIDs may be associated with gastrointestinal, renaland hepatic toxicity. Effects may result from decreased prostaglandinproduction and inhibition of the enzyme cyclooxygenase which is responsible forthe formation of prostaglandins from arachidonic acid.11-14When NSAlDs inhibitprostaglandins that cause inflammation they may also inhibit those prostaglandinswhich maintain normal homeostatic function.Â
Carprofen Caplets,like other drugs of its class, is not free from adverse reactions. Ownersshould be advised of the potential for adverse reactions and be informed of theclinical signs associated with drug intolerance. Adverse reactions may includedecreased appetite, vomiting, diarrhea, dark or tarry stools, increased waterconsumption, increased urination, pale gums due to anemia, yellowing of gums,skin or white of the eye due to jaundice, lethargy, incoordination, seizure, orbehavioral changes.
Always provideClient Information Sheet with prescription. Carefully consider the potentialbenefits and risk of Carprofen and other treatment options before deciding touse Carprofen. Use the lowest effective dose for the shortest durationconsistent with individual response. The recommended dosage for oraladministration to dogs is 2 mg/lb (4.4 mg/kg) of body weight daily.