Moxifloxacin is a member of the fluoroquinolone class ofantibacterial agents
The bactericidal action of moxifloxacin results from inhibitionof the topoisomerase II (DNA gyrase) and topoisomerase I.V. required forbacterial DNA replication, transcription, repair, and recombination. It appearsthat the C8-methoxy moiety contributes to enhanced activity and lower selectionof resistant mutants of Gram-positive bacteria compared to the C8-H moiety. Thepresence of the bulky bicycloamine substituent at the C-7 position preventsactive efflux, associated with theor genes seen in certainGram-positive bacteria.